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doi: 10.3389/fimmu.2022.1051161 Received 22 September 2022 Accepted 02 November 2022 Published 21 November 2022 Volume 13 - 2022 Edited by Maria Carolina Accioly Brelaz de Castro, Federal University of Pernambuco, Brazil Reviewed by Anna E van Beek, Sanquin Diagnostic Services, Netherlands

In another study, researchers revealed that bone marrow mesenchymal stem cells extracted from ALS patients exhibited a decrease in AMPK/SIRT1 signaling, which was subsequently restored through resveratrol treatment [75]

CD11c + myeloid cell-specific FBXL5-deficient mice exhibit higher serum transaminase levels, liver injury, and mortality than the controls

(83), Figure 2)

TXNIP then directly binds to and activates the NLRP3 inflammasome (Zhou et al., 2010